Heat shock proteins 60 and 70 expression of cutaneous lichen planus: comparison with normal skin and psoriasis vulgaris


Bayramgurler D. , Ozkara S. , Apaydin R. , Ercin C., Bilen N.

JOURNAL OF CUTANEOUS PATHOLOGY, cilt.31, ss.586-594, 2004 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 31 Konu: 9
  • Basım Tarihi: 2004
  • Doi Numarası: 10.1111/j.0303-6987.2004.00234.x
  • Dergi Adı: JOURNAL OF CUTANEOUS PATHOLOGY
  • Sayfa Sayısı: ss.586-594

Özet

Background: Heat shock proteins (HSPs) are expressed by most living cells and play fundamental roles in many biological processes. Their synthesis increases by a variety of stresses in order to enable cellular survival. Although it is known that they play an important role in immune and inflammatory responses of the skin, the role of HSPs in the pathogenesis of skin diseases has been studied in only limited skin diseases. Lichen planus (LP) is a relatively common papulosquamous dermatosis, and cell-mediated immunity plays an important role in its pathogenesis. Although an altered expression of certain HSPs was reported in oral LP lesions, the expression of HSPs in cutaneous lesions of LP has not been investigated. In this immunohistochemical study, we aimed at investigating the role of HSPs in the pathogenesis of LP by studying whether there is any difference in HSP expression in cutaneous lesions of LP when compared to normal skin and psoriasis vulgaris (PV).