Continuous venovenous hemodiafiltration to treat controlled-release carbamazepine overdose in a pediatric patient

Yildiz T., Toprak D., Arisoy E. S., Solak M., Toker K.

PEDIATRIC ANESTHESIA, sa.11, ss.1176-1178, 2006 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Basım Tarihi: 2006
  • Doi Numarası: 10.1111/j.1460-9592.2006.01955.x
  • Dergi Adı: PEDIATRIC ANESTHESIA
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1176-1178
  • Kocaeli Üniversitesi Adresli: Evet

Özet

Carbamazepine (CBZ) intoxication is an important issue in acute poisoning practice. Highly protein-bound, CBZ is not removed efficiently through conventional hemodialysis. We describe the use of continuous venovenous hemodiafiltration (CVVHDF) in a 2-year-old boy who developed general tonic clonic seizure and respiratory depression due to controlled-release formula of CBZ overdose (peak drug level of > 20 mu g.ml(-1), therapeutic range: 5-10 mu g.ml(-1)). Serum CBZ concentrations fell to 0.25 mu g.ml(-1) at the end of hemodiafiltration. The patient recovered rapidly and was discharged from hospital 4 days from the time of ingestion with no complications or neurologic impairment.