Continuous venovenous hemodiafiltration to treat controlled-release carbamazepine overdose in a pediatric patient
PEDIATRIC ANESTHESIA, sa.11, ss.1176-1178, 2006 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Basım Tarihi: 2006
- Doi Numarası: 10.1111/j.1460-9592.2006.01955.x
- Dergi Adı: PEDIATRIC ANESTHESIA
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.1176-1178
- Kocaeli Üniversitesi Adresli: Evet
Özet
Carbamazepine (CBZ) intoxication is an important issue in acute poisoning practice. Highly protein-bound, CBZ is not removed efficiently through conventional hemodialysis. We describe the use of continuous venovenous hemodiafiltration (CVVHDF) in a 2-year-old boy who developed general tonic clonic seizure and respiratory depression due to controlled-release formula of CBZ overdose (peak drug level of > 20 mu g.ml(-1), therapeutic range: 5-10 mu g.ml(-1)). Serum CBZ concentrations fell to 0.25 mu g.ml(-1) at the end of hemodiafiltration. The patient recovered rapidly and was discharged from hospital 4 days from the time of ingestion with no complications or neurologic impairment.