Primary thyroid angiosarcoma with liquid based cyto-histopathological findings in a Turkish woman: A rare case report

ACTA OTO-LARYNGOLOGICA CASE REPORTS, vol.9, no.1, pp.47-52, 2024 (ESCI)

destructive behavior, characterized by high mortality rates. We presented the cyto-histopathological

findings of an angiosarcoma case of primarily thyroid origin. A 39-year-old female patient was

presented with thyroid tumor appeared as hemorrhagic, non-encapsulated, with focal cystic

nodules. Histological appearance of the tumor included vascular-like spaces lined with large

epithelioid cells staining positively with factor VIII, CD31. These vascular-like spaces contained

erythrocytes. Retrospective cytology showed that malignant endothelial cells were arranged in

loosely cohesive clusters. These cells had abundant cytoplasm, distinct nucleoli, irregular contoured

and hyperchromatic oval nuclei. This is one of rare cases of primary thyroid angiosarcoma with

sufficient cytological material, showing macroscopic and histopathological findings with

liquid-based cytology. For the diagnosis of thyroid primary angiosarcoma in aspiration, cytological

findings should be evaluated with immunohistochemical methods or, if possible, together with

histopathological findings.