Exenatide Alters Gene Expression of Neural Cell Adhesion Molecule (NCAM), In-tercellular Cell Adhesion Molecule (ICAM), and Vascular Cell Adhesion Molecule (VCAM) in the Hippocampus of Type 2 Diabetic Model Mice

Gumuslu, Esen; ÇİNE, NACİ; Gokbayrak, Merve; MUTLU, OĞUZ; Celikyurt, FERİDE; ULAK, GÜNER

doi:10.12659/msm.897401

Exenatide Alters Gene Expression of Neural Cell Adhesion Molecule (NCAM), In-tercellular Cell Adhesion Molecule (ICAM), and Vascular Cell Adhesion Molecule (VCAM) in the Hippocampus of Type 2 Diabetic Model Mice

Gumuslu E., ÇİNE N., Gokbayrak M. E., MUTLU O., Celikyurt I. K., ULAK G.

MEDICAL SCIENCE MONITOR, cilt.22, ss.2664-2669, 2016 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 22
Basım Tarihi: 2016
Doi Numarası: 10.12659/msm.897401
Dergi Adı: MEDICAL SCIENCE MONITOR
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.2664-2669
Anahtar Kelimeler: Diabetes Mellitus, Genetic Association Studies, Mice, Inbred BALB C, ENDOTHELIAL-CELLS, PEPTIDE-1 RECEPTOR, CEREBRAL-ISCHEMIA, UP-REGULATION, N-CAM, PATHWAY, RAT, MELLITUS, GLP-1, ACID
Kocaeli Üniversitesi Adresli: Evet

Özet

Background: Glucagon-like peptide-1 (GLP-1), a potent and selective agonist for the GLP-1 receptor, ameliorates the symptoms of diabetes through stimulation of insulin secretion. Exenatide is a potent and selective agonist for the GLP-1 receptor. Cell adhesion molecules are members of the immunoglobulin superfamily and are involved in synaptic rearrangements in the mature brain.