Differential expression of leukemia inhibitory factor and insulin like growth factor-1 between normal pregnancies, partial hydatidiform moles and complete hydatidiform moles.

Cicek Ö. S., Hekimoglu E. R., Turgal M., ATİLLA P., Cakar A. N., USUBÜTÜN A., ...Daha Fazla

Placenta, cilt.69, ss.64-70, 2018 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 69
  • Basım Tarihi: 2018
  • Doi Numarası: 10.1016/j.placenta.2018.07.002
  • Dergi Adı: Placenta
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.64-70
  • Anahtar Kelimeler: Hydatidiform mole, Leukemia inhibitory factor (LIF), Insulin like growth factor-1 (IGF-1), Decidua, Trophoblast, Immunohistochemistry, HUMAN-PLACENTA, TROPHOBLAST INVASION, FACTOR LIF, FETOMATERNAL INTERFACE, CHORIOCARCINOMA CELLS, HUMAN ENDOMETRIUM, BINDING, IGF, RECEPTOR, BIOSYNTHESIS
  • Kocaeli Üniversitesi Adresli: Evet

Özet

Introduction: Leukemia inhibitory factor (LIF) and insulin like growth factor-1 (IGF-1) are two of the most important growth factors mediating trophoblast actions. We hypothesized that the localization and expression patterns of LIF and IGF-1 in partial and complete hydatidiform moles (HM) compared with normal first trimester placentas may provide an understanding of the proliferative processes in HMs.