Differential expression of leukemia inhibitory factor and insulin like growth factor-1 between normal pregnancies, partial hydatidiform moles and complete hydatidiform moles.

Cicek Ö. S. , Hekimoglu E. R. , Turgal M., ATİLLA P., Cakar A. N. , USUBÜTÜN A., ...More

Placenta, vol.69, pp.64-70, 2018 (Journal Indexed in SCI Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 69
  • Publication Date: 2018
  • Doi Number: 10.1016/j.placenta.2018.07.002
  • Title of Journal : Placenta
  • Page Numbers: pp.64-70


Introduction: Leukemia inhibitory factor (LIF) and insulin like growth factor-1 (IGF-1) are two of the most important growth factors mediating trophoblast actions. We hypothesized that the localization and expression patterns of LIF and IGF-1 in partial and complete hydatidiform moles (HM) compared with normal first trimester placentas may provide an understanding of the proliferative processes in HMs.