Feasibility of cell therapy in multiple sclerosis: A systematic review of 83 studies

Ardeshirylajimi A., Farshdousti Hagh M., Saki N., Mortaz E., Soleimani M., RAHIM F.

International Journal of Hematology-Oncology and Stem Cell Research, vol.7, no.1, pp.13-30, 2013 (Scopus) identifier

  • Publication Type: Article / Review
  • Volume: 7 Issue: 1
  • Publication Date: 2013
  • Journal Name: International Journal of Hematology-Oncology and Stem Cell Research
  • Journal Indexes: Scopus
  • Page Numbers: pp.13-30
  • Keywords: Hematopoietic stem cells, Human embryonic stem cells, Mesenchymal stem cells, Multiple sclerosis, Neural stem cells, Stem cells therapy
  • Kocaeli University Affiliated: Yes

Abstract

Multiple Sclerosis is an inflammatory disease of the central nervous system in which T cells experienced a second phase of activation, which ultimately leads to axonal demyelination and neurological disability. Recent advancements in stem cell therapies may serve as potential treatments for neurological disorders. There are broad types of stem cells such as neural, embryonic, mesenchymal and hematopoietic stem cells with unprecedented hope in treating many debilitating diseases. In this paper we will review the substantial literature regarding experimental and clinical use of these stem cells and possible mechanisms in the treatment of MS. These results may pave the road for the utilization of stem cells for the treatment of MS.