Morinda citrifolia L. (noni) and memantine attenuate periventricular tissue injury of the fourth ventricle in hydrocephalic rabbits
NEURAL REGENERATION RESEARCH, cilt.8, sa.9, ss.773-782, 2013 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 8 Sayı: 9
- Basım Tarihi: 2013
- Doi Numarası: 10.3969/j.issn.1673-5374.2013.09.001
- Dergi Adı: NEURAL REGENERATION RESEARCH
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.773-782
- Anahtar Kelimeler: neural regeneration, neurodegenerative disease, traditional Chinese medicine, hydrocephalus, Morinda citrifolia L. (noni), memantine, fourth ventricle, periventricular tissue, microtubule-associated protein-2, caspase-3, apoptosis, grants-supported paper, photographs-containing paper, neuroregeneration, VENTRICULOPERITONEAL SHUNT SURGERY, MICROTUBULE-ASSOCIATED PROTEIN-2, NEUROFIBRILLARY TANGLES, NEURONAL PLASTICITY, CEREBROSPINAL-FLUID, ALZHEIMERS-DISEASE, ADULT PATIENTS, TAU, ANTIOXIDANT, EXPRESSION
- Kocaeli Üniversitesi Adresli: Evet
Özet
This study was designed to evaluate the neuroprotective effects of Morinda citrifolia L. (Rubiaceae), commonly known as noni, and memantine (a N-methy-D-aspartate receptor inhibitor) on hydrocephalus-induced neurodegenerative disorders. Kaolin was injected into the cistern magna of male adult New Zealand rabbits to establish a hydrocephalus animal model. Memantine (20 mg/kg, intraperitoneally; memantine-treated group) or noni (5 mL/kg, intragastrically; noni-treated group) was administered daily for 2 weeks. Microtubule-associated protein-2 and caspase-3 immunohistochemistry were performed to detect neuronal degeneration and apoptosis in the periventricular tissue of the fourth ventricle of rabbits. Microtubule-associated protein-2 staining density was significantly decreased in the hydrocephalic group, while the staining density was significantly increased in the memantine- and noni-treated groups, especially in the noni-treated group. Noni treatment decreased the number of caspase-3-positive cells in rabbits with hydrocephalus, while memantine had no effect. These findings suggest that noni exhibits more obvious inhibitory effects on hydrocephalus-induced neurodegenerative disorders than memantine in periventricular tissue of the fourth ventricle.