Morinda citrifolia L. (noni) and memantine attenuate periventricular tissue injury of the fourth ventricle in hydrocephalic rabbits

Kokturk S., Ceylan S., ETUŞ V., Yasa N., CEYLAN S.

NEURAL REGENERATION RESEARCH, vol.8, no.9, pp.773-782, 2013 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 8 Issue: 9
  • Publication Date: 2013
  • Doi Number: 10.3969/j.issn.1673-5374.2013.09.001
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.773-782
  • Keywords: neural regeneration, neurodegenerative disease, traditional Chinese medicine, hydrocephalus, Morinda citrifolia L. (noni), memantine, fourth ventricle, periventricular tissue, microtubule-associated protein-2, caspase-3, apoptosis, grants-supported paper, photographs-containing paper, neuroregeneration, VENTRICULOPERITONEAL SHUNT SURGERY, MICROTUBULE-ASSOCIATED PROTEIN-2, NEUROFIBRILLARY TANGLES, NEURONAL PLASTICITY, CEREBROSPINAL-FLUID, ALZHEIMERS-DISEASE, ADULT PATIENTS, TAU, ANTIOXIDANT, EXPRESSION
  • Kocaeli University Affiliated: Yes


This study was designed to evaluate the neuroprotective effects of Morinda citrifolia L. (Rubiaceae), commonly known as noni, and memantine (a N-methy-D-aspartate receptor inhibitor) on hydrocephalus-induced neurodegenerative disorders. Kaolin was injected into the cistern magna of male adult New Zealand rabbits to establish a hydrocephalus animal model. Memantine (20 mg/kg, intraperitoneally; memantine-treated group) or noni (5 mL/kg, intragastrically; noni-treated group) was administered daily for 2 weeks. Microtubule-associated protein-2 and caspase-3 immunohistochemistry were performed to detect neuronal degeneration and apoptosis in the periventricular tissue of the fourth ventricle of rabbits. Microtubule-associated protein-2 staining density was significantly decreased in the hydrocephalic group, while the staining density was significantly increased in the memantine- and noni-treated groups, especially in the noni-treated group. Noni treatment decreased the number of caspase-3-positive cells in rabbits with hydrocephalus, while memantine had no effect. These findings suggest that noni exhibits more obvious inhibitory effects on hydrocephalus-induced neurodegenerative disorders than memantine in periventricular tissue of the fourth ventricle.