Effect of G-CSF on ethanol-induced hemorrhagic gastritis model in diabetes mellitus-induced rats

Canturk Z., Canturk N. Z. , Cetinarslan B. , Senturk O., Ercin C., Yenise C.

ENDOCRINE RESEARCH, vol.27, pp.191-201, 2001 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 27
  • Publication Date: 2001
  • Doi Number: 10.1081/erc-100107180
  • Title of Journal : ENDOCRINE RESEARCH
  • Page Numbers: pp.191-201


Diabetes mellitus can affect every organ system, including large and small vessels, eyes, nerves, kidneys and gastrointestinal system. Acid peptic disease is an inflammatory condition involving the upper gastrointestinal tract. The elevated serum glucose levels of diabetics affect traditional host defenses such as neutrophil counts and functions. We aimed to investigate changes of gastric mucosa and the role of impaired neutrophil functions in a diabetes-induced experimental model and whether G-CSF, which modulates neutrophil counts and function, has protective effects against gastric mucosal injury in diabetic rats.