Endothelial dysfunction in young women with polycystic ovary syndrome: Relationship with insulin resistance and low-grade chronic inflammation

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Tarkun I., Arslan B., Canturk Z., Turemen E., Sahin T., Duman C.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, vol.89, no.11, pp.5592-5596, 2004 (SCI-Expanded)

• Publication Type: Article / Article
• Volume: 89 Issue: 11
• Publication Date: 2004
• Doi Number: 10.1210/jc.2004-0751
• Journal Name: JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
• Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
• Page Numbers: pp.5592-5596
• Kocaeli University Affiliated: Yes

Abstract

Women with polycystic ovary syndrome (PCOS) carry a number of cardiovascular risk factors. Cardiovascular morbidity is elevated even in young women with PCOS. Low-grade chronic inflammation, reflected in elevated levels of serum C-reactive protein (CRP) and endothelial dysfunction have recently been linked to development of atherosclerosis. We compared high-sensitivity (hs) CRP concentrations and endothelium dysfunction in 37 women with PCOS and 25 control subjects matched as a group for age and body mass index (BMI). Arterial endothelium and smooth muscle function was measured by examining brachial artery responses to endothelium-dependent and endothelium-independent stimuli.