Acute isoniazid poisoning presenting as seizures

Ozmenoglu M., Bolukbasi O., Mocan H., Budak F.

Noropsikiyatri Arsivi, cilt.31, sa.2, ss.63-65, 1994 (Scopus) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 31 Sayı: 2
  • Basım Tarihi: 1994
  • Dergi Adı: Noropsikiyatri Arsivi
  • Derginin Tarandığı İndeksler: Scopus
  • Sayfa Sayıları: ss.63-65
  • Anahtar Kelimeler: Isoniazid, Pyridoxine, Seizures
  • Kocaeli Üniversitesi Adresli: Evet

Özet

Isoniazid is the most effective antituberculous agent yet available. Acute isoniazid poisoning is common in children. More than 30 cases, to our knowledge, have been reported in the literature. Overdose of isoniazid, as in attempted suicide or accidentally may result in uncontrolable convulsions and coma. We report two cases of acute isoniazid intoxication presented with severe convulsions, hyperglycemia and coma and treated with high dose of intravenous pyridoxine hydrochloride successfully.