IN VITRO EFFECTS OF NEW GENERATION BISOXADIAZOLE SUBSTITUTED SULFONAMIDE DERIVATIVES ON HUMAN SERUM PARAOXONASE1 (PON1)


KAYA M. O. , Gulec O., Arslan M.

FRESENIUS ENVIRONMENTAL BULLETIN, vol.27, pp.3351-3358, 2018 (Journal Indexed in SCI) identifier

  • Publication Type: Article / Article
  • Volume: 27
  • Publication Date: 2018
  • Title of Journal : FRESENIUS ENVIRONMENTAL BULLETIN
  • Page Numbers: pp.3351-3358

Abstract

In this study, new bisoxadiazole substituted sulfonamide compounds were synthesized and in vitro inhibition effects of the compouds on purified human serum paraoxonase 1 (PON I) were investigated by using the method of Gan et al. The results showed that all the synthesized compounds inhibited the paraoxonase 1 enzyme activity. The compounds 6d and 6e were found to be most active compounds (IC50=26.5 mu M and 28.6 mu M) for PON1, respectively.