IN VITRO EFFECTS OF NEW GENERATION BISOXADIAZOLE SUBSTITUTED SULFONAMIDE DERIVATIVES ON HUMAN SERUM PARAOXONASE1 (PON1)

KAYA M. O., Gulec O., Arslan M.

FRESENIUS ENVIRONMENTAL BULLETIN, vol.27, pp.3351-3358, 2018 (SCI-Expanded) identifier

  • Publication Type: Article / Article
  • Volume: 27
  • Publication Date: 2018
  • Journal Name: FRESENIUS ENVIRONMENTAL BULLETIN
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED)
  • Page Numbers: pp.3351-3358
  • Kocaeli University Affiliated: Yes

Abstract

In this study, new bisoxadiazole substituted sulfonamide compounds were synthesized and in vitro inhibition effects of the compouds on purified human serum paraoxonase 1 (PON I) were investigated by using the method of Gan et al. The results showed that all the synthesized compounds inhibited the paraoxonase 1 enzyme activity. The compounds 6d and 6e were found to be most active compounds (IC50=26.5 mu M and 28.6 mu M) for PON1, respectively.