IN VITRO EFFECTS OF NEW GENERATION BISOXADIAZOLE SUBSTITUTED SULFONAMIDE DERIVATIVES ON HUMAN SERUM PARAOXONASE1 (PON1)

KAYA M. O., Gulec O., Arslan M.

FRESENIUS ENVIRONMENTAL BULLETIN, cilt.27, ss.3351-3358, 2018 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 27
  • Basım Tarihi: 2018
  • Dergi Adı: FRESENIUS ENVIRONMENTAL BULLETIN
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED)
  • Sayfa Sayıları: ss.3351-3358
  • Kocaeli Üniversitesi Adresli: Evet

Özet

In this study, new bisoxadiazole substituted sulfonamide compounds were synthesized and in vitro inhibition effects of the compouds on purified human serum paraoxonase 1 (PON I) were investigated by using the method of Gan et al. The results showed that all the synthesized compounds inhibited the paraoxonase 1 enzyme activity. The compounds 6d and 6e were found to be most active compounds (IC50=26.5 mu M and 28.6 mu M) for PON1, respectively.