Matrix metalloproteinase 2 (MMP-2) levels are increased in active acromegaly patients

Karci A. C., CANTÜRK Z., Tarkun I., Cetinarslan B.

ENDOCRINE, cilt.57, sa.1, ss.148-155, 2017 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 57 Sayı: 1
  • Basım Tarihi: 2017
  • Doi Numarası: 10.1007/s12020-017-1283-8
  • Dergi Adı: ENDOCRINE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.148-155
  • Anahtar Kelimeler: Acromegaly, Cathepsin B, Matrix metalloproteinase-2, Matrix metalloproteinase-9, HUMAN PITUITARY-ADENOMAS, IGF-I, DIAGNOSTIC-VALUE, GROWTH-HORMONE, CATHEPSIN-B, GH, METAANALYSIS, DISCREPANT, EXPRESSION, PROTEASES
  • Kocaeli Üniversitesi Adresli: Evet

Özet

During follow-up of acromegaly patients, there is a discordance rate of 30% between the measurements of growth hormone and insulin-like growth factor-1 levels. Further tests are required to determine disease activity in patients with discordant results. This study was planned to investigate an association of serum levels of matrix metalloproteinase-2, matrix metalloproteinase-9, and cathepsin B with disease activity in acromegaly patients.