Zinc(II) phthalocyanine containing [2-(tert-butoxycarbonyl)amino] ethoxy and iodine groups (A and B), as well as their deprotected mono-amino and tri-iodinezinc(II) phthalocyanine (2) were obtained. This structure surrounds by substituents with functional groups. From this perspective it can be used a starting material for many reactions and applications, such as sonogashira coupling, carbodiimide coupling. An example of a first diversification reaction of this compound was obtained with conjugation of a biotin. Asymmetrically biotin conjugated and heavy atom bearing zinc(II) phthalocyanine (3) were synthesized characterized for the first time and photophysical, photochemical and photobiological properties of these phthalocyanines were compared in this study. (C) 2016 Elsevier Ltd. All rights reserved.