Microarray-based gene expression analysis of an animal model for closed head injury

ÇOLAK T., Cine N., BAMAÇ B., Kurtas O., OZBEK A., BICER U., ...Daha Fazla

INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED, cilt.43, sa.8, ss.1264-1270, 2012 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 43 Sayı: 8
  • Basım Tarihi: 2012
  • Doi Numarası: 10.1016/j.injury.2012.01.021
  • Dergi Adı: INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1264-1270
  • Anahtar Kelimeler: Rats, Craniocerebral trauma, Microarray, TRAUMATIC BRAIN-INJURY, C1Q FAMILY PROTEINS, MATRIX METALLOPROTEINASES, ENDOTHELIAL-CELLS, GROWTH-FACTOR, ANGIOGENESIS, ISCHEMIA, DEATH, PATHOPHYSIOLOGY, MECHANISMS
  • Kocaeli Üniversitesi Adresli: Evet

Özet

Objective: Traumatic brain injury (TBI) is a major cause of death and disability in both children and the elderly. Mortality from TBI is said account for 1-2% of all deaths. One-third to one-half of all traumatic deaths is due to head injury. Of those who survive, the majority is left with significant disabilities, including 3% who remain in a vegetative state and only approximately 30% who make a good recovery. Microarray studies and other genomic techniques facilitate the discovery of new targets for the treatment of diseases, which aids in drug development, immunotherapeutics and gene therapy. Gene expression profiling or microarray analysis enables the measurement of thousands of genes in a single RNA sample.