Akademik Veri Yönetim Sistemi
Turk Anesteziyoloji ve Reanimasyon Dernegi Dergisi, cilt.38, sa.2, ss.91-100, 2010 (Scopus)
Aim: The aim of this study was to compare in pediatric patients adverse effects, sedative efficacies, and also recovery rates of propofol and ketamine used for magnetic resonance imaging. Material and Method: Hundred and two children aged 6-60 mos were randomly assigned into two groups (ketamine and propofol). After rectal application of 0,6 mg kg -1 midazolam, iv bolus (1,5 mg kg -1) ketamine was administered and the maintenance dosage of ketamine was adjusted as 0,5 mg kg -1 every 15 min in Group K, however in Group P iv bolus propofol (1,5 mg kg -1) was given and the maintenance dosage was set at 100 μg kg -1 min -1. Blood pressure (BP), heart rate (HR), peripheral oxygen saturation (SpO 2), The Children's Hospital of Wisconsin Sedation Scale (CHWSS) for sedation levels and Aldrete scoring for the time to discharge were recorded. Results: In Group P, systolic BP values at 15. minutes, and diastolic BPs at 10., 15., 20., 25., 30., and 35. minutes were lower than Group K (p<0.05). SpO 2 values of Group P were significantly lower at 20. minutes (p<0.05). CHWSS of Group P, at 10.,15., 20., 25., 30., and 35. minutes were found to be lower (p<0.05). Recovery period was also shorter in Group P (p<0.05). One apneic episode was seen in Group P, and 2 cases of irritability were noted in Group K. Conclusion: It was determined that propofol provides deeper sedation, faster recovery when compared with ketamine in pediatric MRI. But ketamine sedation may have advantages especially in children with cardiovascular and/or respiratory risks.