Effect of valsartan versus lisinopril on peritoneal sclerosis in rats

Duman S., Sen S., Duman C., Oreopoulos D.

INTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS, cilt.28, sa.2, ss.156-163, 2005 (SCI-Expanded, Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 28 Sayı: 2
  • Basım Tarihi: 2005
  • Dergi Adı: INTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.156-163
  • Kocaeli Üniversitesi Adresli: Hayır

Özet

Background: Peritoneal sclerosis (PS) is one of the most serious causes of failure in long-term peritoneal dialysis. Angiotensin II is known to promote fibrosis and inflammation in various tissues. We previously showed that ACE inhibitors (ACEIs) have beneficial effects on hypertonic PD solutions (3.86% PD) induced peritoneal alterations. The aim of this study is to compare the effects of an ACEI and a receptor blocker on peritoneal alterations induced by hypertonic PD solutions in rats.