Kinetic Resolution of Oxazinones: Rational Exploration of Chemical Space through the Design of Experiments

Renzi P., Kronig C., Carlone A., Eroksuz S., Berkessel A., Bella M.

CHEMISTRY-A EUROPEAN JOURNAL, cilt.20, sa.37, ss.11768-11775, 2014 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 20 Sayı: 37
  • Basım Tarihi: 2014
  • Doi Numarası: 10.1002/chem.201402380
  • Dergi Adı: CHEMISTRY-A EUROPEAN JOURNAL
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.11768-11775
  • Anahtar Kelimeler: design of experiments, kinetic resolution, organocatalysis, squaramides, thioureas, MICHAEL ADDITION, ORGANOCATALYSTS, OPTIMIZATION, ALCOHOLS
  • Kocaeli Üniversitesi Adresli: Hayır

Özet

The organocatalytic kinetic resolution of 4-substituted oxazinones has been optimised (selectivity factor S up to 98, chiral oxazinone ee values up to 99.6% (1a-g) and product ee values up to 90% (3a-g)) in a rational way by applying the Design of Experiments (DoE) approach.