CHEMISTRY-A EUROPEAN JOURNAL, vol.20, no.37, pp.11768-11775, 2014 (Journal Indexed in SCI)
Article / Article
Title of Journal :
CHEMISTRY-A EUROPEAN JOURNAL
design of experiments, kinetic resolution, organocatalysis, squaramides, thioureas, MICHAEL ADDITION, ORGANOCATALYSTS, OPTIMIZATION, ALCOHOLS
The organocatalytic kinetic resolution of 4-substituted oxazinones has been optimised (selectivity factor S up to 98, chiral oxazinone ee values up to 99.6% (1a-g) and product ee values up to 90% (3a-g)) in a rational way by applying the Design of Experiments (DoE) approach.