Differentiation Potential of Mouse Embryonic Stem Cells into Insulin Producing Cells in Pancreatic Islet Microenvironment

Yilmaz, I.; Sariboyaci, A.; Subasi, C.; Karaoz, E.

doi:10.1055/s-0035-1554720

Differentiation Potential of Mouse Embryonic Stem Cells into Insulin Producing Cells in Pancreatic Islet Microenvironment

Atıf İçin Kopyala

Yilmaz I., Sariboyaci A. E., Subasi C., Karaoz E.

EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES, cilt.124, sa.2, ss.120-129, 2016 (SCI-Expanded)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 124 Sayı: 2
Basım Tarihi: 2016
Doi Numarası: 10.1055/s-0035-1554720
Dergi Adı: EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.120-129
Kocaeli Üniversitesi Adresli: Evet

Özet

Background: The differentiation capacity of embryonic stem cells (ESCs) has great promise for type-1 diabetes for cellular treatment. Therefore, different strategies have been reported so far for derivation of insulin producing cells (IPCs) from ESCs. Providing similar microenvironmental conditions as in vivo, functional differentiation of stem cells into desired cell types could be obtained in vitro. The aim of the present research was to utilize differentiation potential of ESCs to IPCs by co-culture with mouse pancreatic islets (mPIs) for the first time.