Global Gene Expression Analysis of Reactive Stroma in Prostate Cancer


Dakhova O., Ozen M. , Creighton C. J. , Li R., Ayala G., Rowley D., ...More

CLINICAL CANCER RESEARCH, vol.15, no.12, pp.3979-3989, 2009 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 15 Issue: 12
  • Publication Date: 2009
  • Doi Number: 10.1158/1078-0432.ccr-08-1899
  • Title of Journal : CLINICAL CANCER RESEARCH
  • Page Numbers: pp.3979-3989

Abstract

Purpose: Marked reactive stroma formation, designated as grade 3 reactive stroma, is associated with poor outcome in clinically localized prostate cancer. To understand the biological processes and signaling mechanisms underlying the formation of such reactive stroma, we carried out microarray gene expression analysis of laser-captured reactive stroma and matched normal stroma.