Global Gene Expression Analysis of Reactive Stroma in Prostate Cancer

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Dakhova O., Ozen M., Creighton C. J., Li R., Ayala G., Rowley D., ...More

CLINICAL CANCER RESEARCH, vol.15, no.12, pp.3979-3989, 2009 (SCI-Expanded)

• Publication Type: Article / Article
• Volume: 15 Issue: 12
• Publication Date: 2009
• Doi Number: 10.1158/1078-0432.ccr-08-1899
• Journal Name: CLINICAL CANCER RESEARCH
• Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
• Page Numbers: pp.3979-3989
• Kocaeli University Affiliated: No

Abstract

Purpose: Marked reactive stroma formation, designated as grade 3 reactive stroma, is associated with poor outcome in clinically localized prostate cancer. To understand the biological processes and signaling mechanisms underlying the formation of such reactive stroma, we carried out microarray gene expression analysis of laser-captured reactive stroma and matched normal stroma.