An outbreak of oropharyngeal tularaemia linked to natural spring water

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Wilke A., Meric M., Grunow R., SAYAN M. , Finke E. J. , Splettstoesser W., ...Daha Fazla

JOURNAL OF MEDICAL MICROBIOLOGY, cilt.58, ss.112-116, 2009 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 58 Konu: 1
  • Basım Tarihi: 2009
  • Doi Numarası: 10.1099/jmm.0.002279-0
  • Sayfa Sayıları: ss.112-116


A tularaemia outbreak was investigated involving 188 suspected cases in the Kocaeli region of Turkey between December 2004 and April 2005. A case-control study comprising 135 laboratory-confirmed cases and 55 controls was undertaken to identify risk factors for the development of the outbreak and to evaluate laboratory diagnostic methods. Tularaemia was confirmed by a microagglutination test (MAT) titre of >= 1 :160 in 90 of the patients. In MAT-negative sera, 23/44 (52 %) were positive by ELISA with Francisella tularensis LPS and 1/9 (111 %) by Western blotting with this antigen. A species-specific PCR was positive in 16/25 (64 %) throat swabs and 8/13 (62 %) lymph node aspirates. Multivariate analysis showed that drinking natural spring water was the leading risk factor for the development of tularaemia (P=0.0001, odds ratio 0.165, 95 % CI 0.790-0.346). The outbreak ceased after abandonment of the suspected natural water springs.