Nigella sativa and Cancer: A Review Focusing on Breast Cancer, Inhibition of Metastasis and Enhancement of Natural Killer Cell Cytotoxicity

KORAK T., ERGÜL E., SAZCI A.

CURRENT PHARMACEUTICAL BIOTECHNOLOGY, vol.21, no.12, pp.1176-1185, 2020 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Review
  • Volume: 21 Issue: 12
  • Publication Date: 2020
  • Doi Number: 10.2174/1389201021666200430120453
  • Journal Name: CURRENT PHARMACEUTICAL BIOTECHNOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Agricultural & Environmental Science Database, BIOSIS, Biotechnology Research Abstracts, Chemical Abstracts Core, EMBASE, MEDLINE
  • Page Numbers: pp.1176-1185
  • Keywords: Nigella sativa, cancer, breast cancer, metastasis, natural killer cells, tumor surveillance, ACTIVITY IN-VITRO, TUMOR-CELLS, SEED-OIL, ANTIPROLIFERATIVE ACTIVITY, ANTICANCER ACTIVITY, OXIDATIVE STRESS, WILD PLANTS, THYMOQUINONE, L., CARCINOMA
  • Kocaeli University Affiliated: Yes

Abstract

Background: In the last decade, there have been accumulating data that the use of medicinal plants could bring additional benefits to the supportive treatment of various diseases. Nigella sativa (N. sativa, family Ranunculaceae) is one of these plants that has attracted considerable interest. The extracts and seeds of N. sativa and its active component thymoquinone have been studied extensively and the results suggest that N..cativa might carry some therapeutic potential for many diseases, including cancer.