The effect of low temperature plasma nitriding on wear resistance of Ti6Al4V alloy were investigated. There have been several studies to investigate the low temperature plasma nitriding on Ti6Al4V alloy. Plasma nitriding processes under gas mixture of N-2/H-2 = 3 were performed at temperature 535 degrees C for duration of 4, 8 and 12 h. Adhesive wear tests were carried out by using a tribometer in block-on-ring configuration (ASTM G77), in sliding conditions, without lubricants and in air. Surface hardness of the plasma nitrided samples were measured by a Vickers hardness tester machine. Scanning electron microscopy studies were conducted to understand the wear mechanisms involved during the adhesive wear. Wear rate was calculated using weight loss per unit sliding distance. It was found that the wear resistance and surface hardness of the alloy improved considerably after plasma nitriding process. The wear resistance of the plasma nitrided samples were higher than of the unnitrided samples. Extension of nitriding times from 4 h to 12 h in the Ti6Al4V alloy improved remerkably the wear resistance and surface hardness.