Soluble P selectin levels in chronic liver disease: Relationship to disease severity


Vardareli E., Saricam T., Demirustu C. , Gulbas Z.

HEPATO-GASTROENTEROLOGY, vol.54, no.74, pp.466-469, 2007 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 54 Issue: 74
  • Publication Date: 2007
  • Title of Journal : HEPATO-GASTROENTEROLOGY
  • Page Numbers: pp.466-469

Abstract

Background/Aims: Thrombocytopenia and platelet function abnormalities are problems commonly found in patients with chronic liver disease (CLD). Despite lack of widespread recognition as to the clinical significance of Soluble P-selectin (sP-selectin), in that increased levels of sP-selectin have been described in patients with CLD, it has been proposed as a marker of in-vivo platelet activation. The study's aim was to determine whether levels of sP-selectin in patients with CLD increase in accordance with the degree of liver failure, the likelihood of CLD patients with high sP-selectin levels being more prone to thrombosis, as well as investigating the coagulation and fibrinolytic parameters related to the sP-selectin.