Nitric oxide in gingival crevicular fluid and nitric oxide synthase expression in the gingiva of patients with sickle cell disease

Guzeldemir E., Toygar H. U., Bal N., Anarat R., Boga C.

TURKISH JOURNAL OF HEMATOLOGY, cilt.28, sa.2, ss.115-124, 2011 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 28 Sayı: 2
  • Basım Tarihi: 2011
  • Doi Numarası: 10.5152/tjh.2011.27
  • Dergi Adı: TURKISH JOURNAL OF HEMATOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.115-124
  • Anahtar Kelimeler: Sickle cell disease, nitric oxide, nitric oxide synthase, gingival crevicular fluid, gingiva, PERIODONTAL-DISEASE, REPERFUSION INJURY, PORPHYROMONAS-GINGIVALIS, L-ARGININE, MICE, METABOLITES, CRISIS, TISSUE, ISCHEMIA, ANEMIA
  • Kocaeli Üniversitesi Adresli: Evet

Özet

Objective: This study aimed to biochemically measure the production of nitric oxide in gingival crevicular fluid and immunohistochemically measure the expression of inducible nitric oxide synthase in the gingiva of patients with sickle cell disease. Additionally, we aimed to obtain insight into the immunopathology of sickle cell disease by comparing inducible nitric oxide synthase levels in patients with sickle cell disease and controls using gingiva and gingival crevicular fluid.