NS5A resistance - associated substitutions in chronic hepatitis C patients with direct acting antiviral treatment failure in Turkey

SAYAN M., Yildirim F. S., AKHAN S., YILDIRIM A. A., ŞİRİN G., Cabalak M., ...More

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES, vol.95, pp.84-89, 2020 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 95
  • Publication Date: 2020
  • Doi Number: 10.1016/j.ijid.2020.03.061
  • Journal Name: INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, CAB Abstracts, EMBASE, MEDLINE, Veterinary Science Database, Directory of Open Access Journals
  • Page Numbers: pp.84-89
  • Kocaeli University Affiliated: Yes

Abstract

Objectives: Chronic hepatitis C (CHC) is now a more curable disease with new direct acting antivirals (DAA). Although high sustained virologic response rates, failures still occur in DAA regimens. Our objective in this study was to characterize the real-life presence of clinically relevant resistance - associated substitutions (RASs) in the HCV NS5A gene in CHC patients whose DAA regimen has failed.