NS5A resistance - associated substitutions in chronic hepatitis C patients with direct acting antiviral treatment failure in Turkey


SAYAN M. , Yildirim F. S. , AKHAN S. , YILDIRIM A. A. , ŞİRİN G. , Cabalak M., ...More

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES, vol.95, pp.84-89, 2020 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 95
  • Publication Date: 2020
  • Doi Number: 10.1016/j.ijid.2020.03.061
  • Title of Journal : INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
  • Page Numbers: pp.84-89

Abstract

Objectives: Chronic hepatitis C (CHC) is now a more curable disease with new direct acting antivirals (DAA). Although high sustained virologic response rates, failures still occur in DAA regimens. Our objective in this study was to characterize the real-life presence of clinically relevant resistance - associated substitutions (RASs) in the HCV NS5A gene in CHC patients whose DAA regimen has failed.