Relationship between rosacea and chronic obstructive pulmonary disease Rosacea and comorbidities

Demirbas A., Yumer Y., Elmas O. F., Ulutas Demirbas G., Atasoy M., Tursen U., ...More

JOURNAL OF COSMETIC DERMATOLOGY, vol.21, no.5, pp.2255-2262, 2022 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 21 Issue: 5
  • Publication Date: 2022
  • Doi Number: 10.1111/jocd.14389
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, EMBASE, MEDLINE
  • Page Numbers: pp.2255-2262
  • Keywords: chronic obstructive pulmonary disease, rosacea, spirometry, ANTIMICROBIAL PEPTIDE LL-37, INCREASED RISK, PATHOGENESIS, STANDARDIZATION, INFLAMMATION, ACTIVATION, COPD
  • Kocaeli University Affiliated: Yes


Background Rosacea is a chronic inflammatory skin disease that has been reported to be associated with many systemic disorders including respiratory diseases. Aims This study aims to investigate respiratory function in patients with rosacea. Patients/Methods Patients with rosacea and age- and gender-matched healthy volunteers were included in this cross-sectional study. Spirometric pulmonary function tests including the percentage of forced vital capacity (FVC%), percentage of forced expiratory volume in one second (FEV 1%), forced expiratory flow at 25-75% of FVC (FEF 25-75%), and FEV 1/FVC ratio was assessed in both patient and controls. The potential relationship between rosacea severity and pulmonary functions was assessed. Results A total of 120 patients with rosacea and 120 healthy controls were enrolled in the study. Compared to the controls, FEV 1%, FEV 1/FVC%, and FEF 25-75% values were significantly lower in patients with rosacea. Lower FEV 1/FVC% values were found to be associated with disease severity. FEV 1%, FEV 1/FVC%, and FEF 25-75% values were found to be more useful in differentiating the patients from healthy subjects. Conclusions This study showed that patients with rosacea may have abnormal respiratory function compared to healthy subjects. Besides, disease severity was associated with worse respiratory functions. We believe that patients with rosacea, particularly those with additional risk factors, should be screened for respiratory disorders.