Effects of isotretinoin on serum vitamin E levels in patients with acne.


Aktürk A. , Güzel S., Bulca S., Demirsoy E. , Bayramgürler D. , Bilen N., ...Daha Fazla

International journal of dermatology, cilt.52, ss.363-6, 2013 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 52 Konu: 3
  • Basım Tarihi: 2013
  • Doi Numarası: 10.1111/j.1365-4632.2012.05676.x
  • Dergi Adı: International journal of dermatology
  • Sayfa Sayıları: ss.363-6

Özet

Anecdotal reports suggest that using retinoids with vitamin E leads to improvements of some side effects due to isotretinoin. However, vitamin E blood levels have not been reported previously in patients with acne treated with isotretinoin. We aimed to investigate the serum vitamin E levels before and after isotretinoin therapy in patients with acne. A total of 70 patients treated with isotretinoin for acne in our dermatology department were included in this study. The serum vitamin E levels were measured as baseline before isotretinoin treatment. All patients received 0.60.8mg/kg/d isotretinoin. The treatment was finished within 57months while ensuring that the cumulative dose was 120mg/kg. Serum vitamin E levels were measured again in the last month of treatment. The mean serum vitamin E levels before and after treatment were compared. Forty-six patients completed the study. It was detected that the mean serum vitamin E level was 20.22mg/dl before isotretinoin treatment. In the last month of treatment, the mean serum vitamin E level was 16.24mg/dl. Serum vitamin E levels decreased in all patients except three. The mean serum vitamin E level after treatment was statistically decreased in comparison with the mean serum vitamin E level before treatment. Our results showed that vitamin E levels decreased during isotretinoin treatment. We considered that some of the side effects due to isotretinoin treatment might be related to this, and supplementation vitamin E may be useful during isotretinoin treatment.