The antinociceptive effect and mechanisms of action of pregabalin in mice


Kaygisiz B., Kilic F. S. , Senguleroglu N., Baydemir C. , Erol K.

PHARMACOLOGICAL REPORTS, vol.67, no.1, pp.129-133, 2015 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 67 Issue: 1
  • Publication Date: 2015
  • Doi Number: 10.1016/j.pharep.2014.08.013
  • Title of Journal : PHARMACOLOGICAL REPORTS
  • Page Numbers: pp.129-133

Abstract

Background: Pregabalin, a potent anticonvulsant agent, is used in treatment-resistant epileptic patients. It is reported that pregabalin also has analgesic effect in different pain syndromes. However, there is limited data on its antinociceptive mechanisms of action. We aimed to investigate the central and peripheral antinociceptive effects of pregabalin and the contribution of nitrergic, serotonergic, and opioidergic pathways in mice.