The antinociceptive effect and mechanisms of action of pregabalin in mice

Kaygisiz B., Kilic F. S. , Senguleroglu N., Baydemir C. , Erol K.

PHARMACOLOGICAL REPORTS, cilt.67, sa.1, ss.129-133, 2015 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 67 Konu: 1
  • Basım Tarihi: 2015
  • Doi Numarası: 10.1016/j.pharep.2014.08.013
  • Sayfa Sayıları: ss.129-133


Background: Pregabalin, a potent anticonvulsant agent, is used in treatment-resistant epileptic patients. It is reported that pregabalin also has analgesic effect in different pain syndromes. However, there is limited data on its antinociceptive mechanisms of action. We aimed to investigate the central and peripheral antinociceptive effects of pregabalin and the contribution of nitrergic, serotonergic, and opioidergic pathways in mice.