The antinociceptive effect and mechanisms of action of pregabalin in mice

Kaygisiz B., Kilic F. S., Senguleroglu N., Baydemir C., Erol K.

PHARMACOLOGICAL REPORTS, vol.67, no.1, pp.129-133, 2015 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 67 Issue: 1
  • Publication Date: 2015
  • Doi Number: 10.1016/j.pharep.2014.08.013
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.129-133
  • Kocaeli University Affiliated: Yes


Background: Pregabalin, a potent anticonvulsant agent, is used in treatment-resistant epileptic patients. It is reported that pregabalin also has analgesic effect in different pain syndromes. However, there is limited data on its antinociceptive mechanisms of action. We aimed to investigate the central and peripheral antinociceptive effects of pregabalin and the contribution of nitrergic, serotonergic, and opioidergic pathways in mice.