Serum hepcidin and growth differentiation factor-15 (GDF-15) levels in polycythemia vera and essential thrombocythemia

TARKUN, PINAR; MEHTAP, ÖZGÜR; Atesoglu, Elif; GEDÜK, AYFER; Musul, Mahmut; Hacihanefioglu, ABDULLAH

doi:10.1111/ejh.12150

Serum hepcidin and growth differentiation factor-15 (GDF-15) levels in polycythemia vera and essential thrombocythemia

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TARKUN P. , MEHTAP Ö. , Atesoglu E. B. , GEDÜK A. , Musul M. M. , Hacihanefioglu A.

EUROPEAN JOURNAL OF HAEMATOLOGY, vol.91, no.3, pp.228-235, 2013 (Journal Indexed in SCI)

Publication Type: Article / Article
Volume: 91 Issue: 3
Publication Date: 2013
Doi Number: 10.1111/ejh.12150
Title of Journal : EUROPEAN JOURNAL OF HAEMATOLOGY
Page Numbers: pp.228-235

Abstract

Objectives Hepcidin plays a regulatory role in systemic iron homeostasis. GDF-15 has been found to be expressed from matured erythroblasts and very high levels of GDF-15 suppresses hepcidin secretion. In this study, we evaluated hepcidin and GDF-15 levels in polycythemia vera (PV) and essential thrombocythemia (ET).