Serum hepcidin and growth differentiation factor-15 (GDF-15) levels in polycythemia vera and essential thrombocythemia

TARKUN P., MEHTAP Ö., Atesoglu E. B., GEDÜK A., Musul M. M., Hacihanefioglu A.

EUROPEAN JOURNAL OF HAEMATOLOGY, vol.91, no.3, pp.228-235, 2013 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 91 Issue: 3
  • Publication Date: 2013
  • Doi Number: 10.1111/ejh.12150
  • Journal Name: EUROPEAN JOURNAL OF HAEMATOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.228-235
  • Keywords: polycythemia vera, essential thrombocythemia, hepcidin, growth differentiation factor-15, EXPRESSION, ERYTHROPOIETIN, PROHEPCIDIN, FERROPORTIN
  • Kocaeli University Affiliated: Yes

Abstract

Objectives Hepcidin plays a regulatory role in systemic iron homeostasis. GDF-15 has been found to be expressed from matured erythroblasts and very high levels of GDF-15 suppresses hepcidin secretion. In this study, we evaluated hepcidin and GDF-15 levels in polycythemia vera (PV) and essential thrombocythemia (ET).