Rapamycin Improves Vascular Remodelling in a Controlled Rat Model of Monocrotaline-Induced Pulmonary Hypertension

Sengul A., Vural C., Arkan S., Ozer C., Bayrak B. Y., Tas A., ...More

WEST INDIAN MEDICAL JOURNAL, vol.69, no.9, pp.638-644, 2023 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 69 Issue: 9
  • Publication Date: 2023
  • Doi Number: 10.7727/wimj.2015.222
  • Journal Name: WEST INDIAN MEDICAL JOURNAL
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, CAB Abstracts, CINAHL, EMBASE, Veterinary Science Database
  • Page Numbers: pp.638-644
  • Keywords: Life expectancy, pulmonary hypertension, rapamycin, vascular remodelling, ARTERIAL-HYPERTENSION, CELL PROLIFERATION, MTOR, EVEROLIMUS, EXPRESSION, INHIBITORS, SIROLIMUS, FIBROSIS, THERAPY, TARGET
  • Kocaeli University Affiliated: Yes

Abstract

Background: Pulmonary arterial hypertension (PAH) is a serious disease characterized by the progressive elevation of the pulmonary arterial resistance, leading to the right ventricular failure and death.