Akademik Veri Yönetim Sistemi
TURKISH JOURNAL OF ENDOCRINOLOGY AND METABOLISM, cilt.11, sa.2, ss.67-69, 2007 (ESCI)
Only a small number of adult patients with persistant hyperinsulinemic hypogycemia (PHH) without insulinoma were reported in the recent years. We want to discuss a 73-year-old man with PHH who was brought in to the emergency service with a low blood glucose level. Subtotal pancreatectomy was performed under general anesthesia without a tumoral mass. The histopathological examination revealed ductuloinsular complexes. One giant islet measuring 800 mu m x 300 mu m was observed. The mean islet diameter was 270 mu m, and 24 % of the islets were over 300 mu m in size. The mean beta cell nucleus diameter was 7.27 mu m (5.28 mu m in the control group). Postoperatively, patient's blood glucose measurements remained within normal limits. In conclusion; ductuloinsular complex formation, islet cell hyperplasia and Ki-67 immunolabeling are not valuable diagnostic criteria for the diagnosis of adulthood nesidioblastosis. The most valuable histopathological feature is beta cell nucleus size.