Treatment with chitin microparticles is protective against lung histopathology in a murine asthma model

Ozdemir C., Yazi D., Aydogan M., Akkoc T., Bahceciler N. N., Strong P., ...More

CLINICAL AND EXPERIMENTAL ALLERGY, vol.36, no.7, pp.960-968, 2006 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 36 Issue: 7
  • Publication Date: 2006
  • Doi Number: 10.1111/j.1365-2222.2006.02515.x
  • Journal Name: CLINICAL AND EXPERIMENTAL ALLERGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.960-968
  • Keywords: airway histopathology, asthma, BALB/c, chitin microparticles, ACIDIC MAMMALIAN CHITINASE, HEAT-KILLED LISTERIA, T-CELL CYTOKINES, CPG OLIGODEOXYNUCLEOTIDES, ATOPIC ASTHMA, INFLAMMATION, MODULATION, RESPONSES, ADJUVANT, IMMUNITY
  • Kocaeli University Affiliated: Yes

Abstract

Chitin, a natural polysaccharide extracted from shrimp, is a potent T and B cell adjuvant when delivered in the form of chitin microparticles and can shift a polarized T-helper type 2 (Th2) immune response towards a Th1 response.