The Effect of Recombinant Tyrosine Hydroxylase Expression on the Neurogenic Differentiation Potency of Mesenchymal Stem Cells

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Turac G., Duruksu G., Karaöz E.

NEUROSPINE, cilt.15, ss.42-53, 2018 (Hakemli Dergi) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 15
  • Basım Tarihi: 2018
  • Doi Numarası: 10.14245/ns.1836010.005
  • Dergi Adı: NEUROSPINE
  • Sayfa Sayıları: ss.42-53
  • Anahtar Kelimeler: Tyrosine hydroxylase, Differentiation, Gene expression, Neuroprotection, Mesenchymal stem cell, BONE-MARROW, RAT MODEL, GENE-TRANSFER, SPINAL-CORD, TRANSPLANTATION, THERAPY, BRAIN, PROLIFERATION, DOPAMINE, PROTECTS
  • Kocaeli Üniversitesi Adresli: Evet

Özet

Objective: Tyrosine hydroxylase (TH) is a rate-limiting enzyme in dopamine synthesis, making the enhancement of its activity a target for ensuring sufficient dopamine levels. Rat bone marrow mesenchymal stem cells (rBM-MSCs) are known to synthesize TH after differentiating into neuronal cells through chemical induction, but the effect of its ectopic expression on these cells has not yet been determined. This study investigated the effects of ectopic recombinant TH expression on the stemness characteristics of rBM-MSCs.