Effects of Adipokinetic Hormone/Red Pigment-Concentrating Hormone (AKH/RPCH) Family of Peptides on Uterine Contraction


MUTLU O. , Tanyeri P., Akdemir N., Buyukokuroglu M. E. , Akar F., ULAK G. , ...Daha Fazla

INTERNATIONAL JOURNAL OF MEDICAL RESEARCH & HEALTH SCIENCES, cilt.7, ss.63-67, 2018 (ESCI İndekslerine Giren Dergi) identifier

  • Cilt numarası: 7 Konu: 6
  • Basım Tarihi: 2018
  • Dergi Adı: INTERNATIONAL JOURNAL OF MEDICAL RESEARCH & HEALTH SCIENCES
  • Sayfa Sayıları: ss.63-67

Özet

Objective: Many processes in insects, including metabolic, behavioral, developmental, and reproductive processes, are altered by neuropeptides. Adipokinetic hormone/red pigment-concentrating hormone (AKH/RPCH) family of peptides include adipokinetic and hypertrehalosemic peptides. Methods: The present study investigated the effects of Anax imperator AKH (Ani-AKH), Libellula auripennis AKH (Lia-AKH), Phormia terraenovae hypertrehalosemic hormone (Pht-HrTH) and oxytocin on uterine contractility in human uterus strips. Contraction formed by Ani-AKH, Lia-AKH, Pht-HrTH and oxytocin were obtained from percentages of the maximal contraction of KCl (80 mM). Results: No difference detected between contractions of Ani-AKH, Lia-AKH, or Pht-HrTH and oxytocin at doses of 10 -8 M in human uterus strips. Lia-AKH (10(-7)-10(-4) M) significantly increased uterine contractions compared to oxytocin (10(-7)-10(-4) M) in human uterus strips. Both Ani-AKH (10(-4) M) and Lia-AKH (10(-4) M) significantly increased uterine contractions compared to oxytocin (10(-4 )M) in human uterus strips. Conclusion: These results show that the AKHs examined can be used to induce human uterine contraction.