The role of ATP-binding cassette transporter genes in the progression of prostate cancer

Karatas O. F., Guzel E., Duz M. B., Ittmann M., ÖZEN M.

PROSTATE, vol.76, no.5, pp.434-444, 2016 (SCI-Expanded, Scopus) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 76 Issue: 5
  • Publication Date: 2016
  • Doi Number: 10.1002/pros.23137
  • Journal Name: PROSTATE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.434-444
  • Keywords: prostate cancer, recurrence, ABC transporters, progression, prognosis, ABC TRANSPORTERS, MULTIDRUG-RESISTANCE, HISTONE MODIFICATIONS, EXPRESSION, PROGNOSIS, ADENOCARCINOMA, POLYMORPHISMS, INVOLVEMENT, RECURRENCE, MARKERS
  • Kocaeli University Affiliated: No

Abstract

BACKGROUNDProstate cancer (PCa) is the most commonly diagnosed neoplasm and the second leading cause of cancer-related death among men in developed countries. There is no clear evidence showing the success of current screening tests in reducing mortality of PCa. In this study, we aimed to profile expressions of nine ABC transporters, ABCA5, ABCB1, ABCB6, ABCC1, ABCC2, ABCC3, ABCC5, ABCC10, and ABCF2, in recurrent, non-recurrent PCa and normal prostate tissues.