Monitoring of hepatitis B virus surface antigen escape mutations and concomitantly nucleos(t)ide analog resistance mutations in Turkish patients with chronic hepatitis B

SAYAN, MURAT; Senturk, O.; AKHAN, SILA; HÜLAGÜ, SADETTİN; Cekmen, M.

doi:10.1016/j.ijid.2009.11.039

Monitoring of hepatitis B virus surface antigen escape mutations and concomitantly nucleos(t)ide analog resistance mutations in Turkish patients with chronic hepatitis B

SAYAN M., Senturk O., AKHAN S., HÜLAGÜ S., Cekmen M. B.

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES, cilt.14, 2010 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 14
Basım Tarihi: 2010
Doi Numarası: 10.1016/j.ijid.2009.11.039
Dergi Adı: INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
Kocaeli Üniversitesi Adresli: Evet

Özet

Background: The hepatitis B virus (HBV) polymerase gene completely overlaps with the envelope gene. In the present study we aimed to monitor the prevalence and pattern of the typical mutations for hepatitis B surface antigen (HBsAg) escape, and concomitantly nucleos(t)ide analog (NUC) resistance mutations, in Turkish patients undergoing different antiviral therapies and in treatment-naive patients with chronic hepatitis B (CHB).