Monitoring of hepatitis B virus surface antigen escape mutations and concomitantly nucleos(t)ide analog resistance mutations in Turkish patients with chronic hepatitis B

SAYAN, MURAT; Senturk, O.; AKHAN, SILA; HÜLAGÜ, SADETTİN; Cekmen, M.

doi:10.1016/j.ijid.2009.11.039

Monitoring of hepatitis B virus surface antigen escape mutations and concomitantly nucleos(t)ide analog resistance mutations in Turkish patients with chronic hepatitis B

Copy For Citation

SAYAN M., Senturk O., AKHAN S., HÜLAGÜ S., Cekmen M. B.

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES, vol.14, 2010 (SCI-Expanded)

Publication Type: Article / Article
Volume: 14
Publication Date: 2010
Doi Number: 10.1016/j.ijid.2009.11.039
Journal Name: INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Kocaeli University Affiliated: Yes

Abstract

Background: The hepatitis B virus (HBV) polymerase gene completely overlaps with the envelope gene. In the present study we aimed to monitor the prevalence and pattern of the typical mutations for hepatitis B surface antigen (HBsAg) escape, and concomitantly nucleos(t)ide analog (NUC) resistance mutations, in Turkish patients undergoing different antiviral therapies and in treatment-naive patients with chronic hepatitis B (CHB).