Akademik Veri Yönetim Sistemi
ARCHIVES OF PSYCHIATRY AND PSYCHOTHERAPY, cilt.19, sa.3, ss.27-33, 2017 (ESCI, Scopus)
Background: Opium addiction is a common and disabling disease. Despite patients' interest in herbal remedies, there is lack of valid evidence in the context of herbal treatment for opium withdrawal symptoms, which hinders treatment. Thyme leaves are used in traditional medicine to relieve pain and for seizure control. Aims: To compare the effect of an alcoholic extract of Zataria multiflora Boiss [thyme extract] with methadone in controlling the symptoms of opium withdrawal. Methodology: In a double-blind, randomized clinical trial, an alcoholic extract of thyme plus methadone were given to 40 patients and compared with a group receiving methadone with placebo. Withdrawal symptoms in days 0, 2, 7, 11 and 15 were evaluated with the Clinical Institute Narcotic Assessment (CINA) scale. Results: Withdrawal symptoms were controlled in both study groups and were tolerated when reducing the methadone dose in the thyme group. Conclusion: Alcoholic thyme extract can be used as an effective agent in controlling the symptoms of opium withdrawal and should be further investigated.