Metabolomics analysis of mesenchymal stem cells
International Journal of Molecular and Cellular Medicine, cilt.8, ss.30-40, 2019 (Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 8
- Basım Tarihi: 2019
- Doi Numarası: 10.22088/iijmcm.bums.8.2.30
- Dergi Adı: International Journal of Molecular and Cellular Medicine
- Derginin Tarandığı İndeksler: Scopus
- Sayfa Sayıları: ss.30-40
- Anahtar Kelimeler: Mesenchymal stem cells, Metabolic pathways, Metabolomics, Systems biology
- Kocaeli Üniversitesi Adresli: Evet
Özet
Various mesenchymal stem cells as easily accessible and multipotent cells can share different essential signaling pathways related to their stemness ability. Understanding the mechanism of stemness ability can be useful for controlling the stem cells for regenerative medicine targets. In this context, OMICs studies can analyze the mechanism of different stem cell properties or stemness ability via a broad range of current high-throughput techniques. This field is fundamentally directed toward the analysis of whole genome (genomics), mRNAs (transcriptomics), proteins (proteomics) and metabolites (metabolomics) in biological samples. According to several studies, metabolomics is more effective than other OMICs for various system biology concerns. Metabolomics can elucidate the biological mechanisms of various mesenchymal stem cell function by measuring their metabolites such as their secretome components. Analyzing the metabolic alteration of mesenchymal stem cells can be useful to promote their regenerative medicine application.