Chronic Effects of Loxapine, Iloperidone, Paliperidone on Mice Isolated Vas Deferens Contractility

Tanyeri M. H., Büyükokuroğlu M. E., Tanyeri P., Kaya R. K., Başarır Ş. N., Mutlu O., ...Daha Fazla

Online Türk Sağlık Bilimleri Dergisi, cilt.7, sa.1, ss.40-46, 2022 (Hakemli Dergi)

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 7 Sayı: 1
  • Basım Tarihi: 2022
  • Dergi Adı: Online Türk Sağlık Bilimleri Dergisi
  • Derginin Tarandığı İndeksler: TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.40-46
  • Kocaeli Üniversitesi Adresli: Evet

Özet

Objective: Erectile dysfunction is a usual side effect of antipsychotic medications; this causes patients to avoid using drugs. The aim of this study to investigate the ef-fects of iloperidone, paliperidone and loxapine on sero-tonin (5-HT), noradrenaline (NA), adenosine triphosphate (ATP) and potassium chloride (KCl)-induced contractions of the vas deferens in mice.

Materials and Methods: The mice were randomly di-vided into experimental groups and treated by ip injection of drugs for 21 days. After the treatment, the effects of drugs were investigated on 5-HT, ATP, NA and KCl-induced contractile responses in the epididymal and prostatic portions of mice vas deferens strips.

Results: 5-HT-induced contractile responses were signifi-cantly increased while ATP-induced contractile responses were significantly decreased in the both portions of the vas deferens obtained from the iloperidone, paliperidone and loxapine-treated groups. However, these drugs had no significant effect on NA- and KCl-induced contractions of mice vas deferens.

Conclusion: These results showed that serotonin and ATP-induced contractions of vas deferens were affected by the chronic treatments of iloperidone, paliperidone, and loxap-ine. In mice chronically treated with these drugs, seroton-ergic and purinergic receptors may contribute to changes in vas deferens contractions that cause erectile dysfunc-tion.