Community-acquired CTX-M-15-type ESBL-producing Escherichia coli meningitis: a case report and literature review


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ELALDI N., Gozel M. G. , KOLAYLI F. , ENGİN A., ÇELİK C., BAKICI M. Z. , ...More

JOURNAL OF INFECTION IN DEVELOPING COUNTRIES, vol.7, no.5, pp.424-431, 2013 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Review
  • Volume: 7 Issue: 5
  • Publication Date: 2013
  • Doi Number: 10.3855/jidc.2820
  • Title of Journal : JOURNAL OF INFECTION IN DEVELOPING COUNTRIES
  • Page Numbers: pp.424-431

Abstract

In this report, a case of community-acquired acute bacterial meningitis (CA-ABM) caused by CTX-M-15-producing Escherichia coli in an elderly male patient was presented in the light of literature. Cultures of cerebrospinal fluid, blood, ear discharge, and stool samples yielded CTX-M-15-producing E. coli in-vitro, which was resistant to the extended-spectrum cephalosporins and ciprofloxacin and susceptible to imipenem, meropenem and amikacin. Meningitis was treated with parenteral meropenem plus parenteral and intraventricular amikacin administration. Since bacterial meningitis is a life-threatening infection, empiric antibiotic therapy with carbapenem can be started before the culture results are obtained, mainly in areas where the ESBL epidemiology is well known.