The effects of chronic treatment with a calcium channel antagonist on two types of generalized epilepsies in rats

van Luijtelaar E., Ates N., van der Staay F.

Pharmacology, Biochemistry and Behavior, vol.48, no.3, pp.575-579, 1994 (SCI-Expanded) identifier identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 48 Issue: 3
  • Publication Date: 1994
  • Doi Number: 10.1016/0091-3057(94)90316-6
  • Journal Name: Pharmacology, Biochemistry and Behavior
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.575-579
  • Keywords: NIMODIPINE, CALCIUM ANTAGONIST, PENTYLENETETRAZOL-INDUCED SEIZURES, ABSENCE EPILEPSY, SPIKE-WAVE DISCHARGES, GENETIC EPILEPSY MODEL, CHRONIC ADMINISTRATION, WISTAR RATS, AGING, SPIKE-WAVE DISCHARGES, ABSENCE EPILEPSY, INDUCED SEIZURES, ANTICONVULSANT PROPERTIES, NEURONS, SUPPRESSION, NIMODIPINE, PAROXYSMS, PATTERNS, BLOCKERS
  • Kocaeli University Affiliated: Yes

Abstract

We study the most general Multi-Higgs-Doublet Model (MHDM) with Natural Flavor Conservation (NFC). The couplings of a charged scalar $H_i^{\pm}$ to up quarks, down quarks and charged leptons depend on three new complex parameters, $X_i$, $Y_i$ and $Z_i$, respectively. We prove relations among these parameters. We carry out a comprehensive analysis of phenomenological constraints on the couplings of the lightest charged scalar: $X$, $Y$ and $Z$. We find that the general MHDM may differ significantly from its minimal version, the Two-Higgs-Doublet Model (2HDM).