Abundant proteins in platelet-rich fibrin and their potential contribution to wound healing: An explorative proteomics study and review of the literature

Yaprak E., Kasap M., Akpınar G., İşlek E. E., Sinanoglu A.

JOURNAL OF DENTAL SCIENCES, vol.13, no.4, pp.386-395, 2018 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Review
  • Volume: 13 Issue: 4
  • Publication Date: 2018
  • Doi Number: 10.1016/j.jds.2018.08.004
  • Journal Name: JOURNAL OF DENTAL SCIENCES
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.386-395
  • Keywords: Platelet-rich fibrin, Proteomics, MALDI, Blood proteins, ACUTE-PHASE PROTEIN, ENDOTHELIAL GROWTH-FACTOR, II FURCATION DEFECTS, CHRONIC PERIODONTITIS, 1-PERCENT ALENDRONATE, TOPICAL APPLICATION, INTRABONY DEFECTS, TRYPSIN INHIBITOR, CELL-MIGRATION, C1 INHIBITOR
  • Kocaeli University Affiliated: Yes

Abstract

Background/purpose: It is well-known that diverse types of blood proteins contribute to healing process via different mechanisms. Presence and potential involvements of blood-derived abundant proteins in the platelet-rich fibrin (PRF) to its regenerative capacity have not been sufficiently emphasized in the literature. The aim of this paper was to analyze the abundant proteome content of PRF and summarize previously reported effects of identified proteins on wound healing via a literature review.