Decreased plasminogen activator inhibitor-1 levels in coronary artery aneurysmatic patients


Ercan E., Tengiz I., Duman C., Sekuri C., Aliyev E., Mutlu B., ...Daha Fazla

JOURNAL OF THROMBOSIS AND THROMBOLYSIS, cilt.17, ss.207-211, 2004 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 17 Konu: 3
  • Basım Tarihi: 2004
  • Doi Numarası: 10.1023/b:thro.0000040490.00796.30
  • Dergi Adı: JOURNAL OF THROMBOSIS AND THROMBOLYSIS
  • Sayfa Sayıları: ss.207-211

Özet

Background: Matrix metalloproteinases (MMPs) have been implicated in the pathogenesis of arterial aneurysms through increased proteolysis of extracellular matrix proteins. Increased proteolysis due to elevated matrix degrading enzyme activity in the arterial wall may act as a susceptibility factor for the development of coronary aneurysms. Plasmin strongly stimulates pro-MMP enzyme conversion to the active form. Plasmin hyperactivity due to decreased plasminogen activator inhibitor-1 (PAI-1) may cause MMP over activity and coronary aneurysms. The aim of this study was to investigate the association between PAI-1 and presence of coronary aneurysms.