CCR5-?32 gene variant frequency in the Nigerian and Zimbabwean populations living in North Cyprus

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Ndikom B. C., Ergoren M. C., Sayan M., Mocan G., FAHRİOGLU U.

AFRICAN HEALTH SCIENCES, cilt.22, sa.1, ss.361-366, 2022 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 22 Sayı: 1
  • Basım Tarihi: 2022
  • Doi Numarası: 10.4314/ahs.v22i1.44
  • Dergi Adı: AFRICAN HEALTH SCIENCES
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, CAB Abstracts, EMBASE, Index Islamicus, MEDLINE, Pollution Abstracts, Veterinary Science Database
  • Sayfa Sayıları: ss.361-366
  • Anahtar Kelimeler: CCR5-?32, HIV, Nigerian, Zimbabwean, CCR5, North Cyprus, HIV-1 INFECTION, CCR5-DELTA-32, PROGRESSION, DISEASE, ALLELE
  • Kocaeli Üniversitesi Adresli: Evet

Özet

Background: The cystine-cystine chemokine receptor 5 (CCR5) is the primary HIV co-receptor involved in the viral entry process into human cells. The 32 bp deletion variant within the CCR5 gene (CCR5-??32) plays a very important role in viral recogni- tion and progression of AIDS. Objective: The current study was aimed at evaluating the CCR5-??32 gene variation frequency in Nigerian and Zimbabwean pop- ulations residing in Northern Cyprus. Methods: A total number of 211 subjects (103 Nigerians and 108 Zimbabweans) were analyzed. Nigerian population was further analyzed with respect to the three major ethnicities: Igbo, Hausa, and Yoruba. Polymerase Chain Reaction was used to determine the CCR5-??32 gene variant status. Results: All studied subjects from both sampling groups were homozygous for the CCR5 wild type gene (CCR5???wt), meaning neither heterozygous nor homozygous genotypes of CCR5-??32 gene variant were observed. Conclusion: This study observed the absence of CCR5-??32 deletion gene in the Nigeria and Zimbabwean populations living in Northern Cyprus. These populations lack the genetic advantage over HIV infection and may also show a rapid progression towards AIDS. Additionally, these populations could impact the local gene frequency as these two populations interact more and more.