Effect of pentylenetetrazole and sound stimulation induced single and repeated convulsive seizures on the MDA, GSH and NO levels, and SOD activities in rat liver and kidney tissues

DİLLİOĞLUGİL M. Ö., Kir H., Demir C., İLBAY G., ŞAHİN D., DİLLİOĞLUGİL Ö., ...More

BRAIN RESEARCH BULLETIN, vol.83, no.6, pp.356-359, 2010 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 83 Issue: 6
  • Publication Date: 2010
  • Doi Number: 10.1016/j.brainresbull.2010.09.007
  • Journal Name: BRAIN RESEARCH BULLETIN
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.356-359
  • Keywords: Epilepsy, Seizure, Pentylenetetrazole, MDA, NO, SOD, GSH, Liver, Kidney, INDUCED EPILEPTIC SEIZURE, THIOL REDOX STATE, OXIDATIVE STRESS, NITRIC-OXIDE, LIPID-PEROXIDATION, WAG/RIJ RATS, BRAIN, MICE, MODEL, ACID
  • Kocaeli University Affiliated: Yes

Abstract

Objectives The aim of our study was to evaluate the activity of superoxide dismutase (SOD) and the levels of glutathione (GSH) malondialdehyde (MDA) and nitric oxide (NO) in liver and kidney tissues in a rat model of convulsive seizure induced by single and repeated doses of pentylenetetrazole (PTZ) and sound stimulation with key ringing