Silibinin Effect on Methotrexate-Induced Hepatotoxicity in Rats

yavaşoğlu e., BÜYÜKAVCI M., ÇETİNKAYA A., TURAN G., KÖROĞLU M., YAZAR H., ...Daha Fazla

EURASIAN JOURNAL OF MEDICINE, cilt.54, sa.3, ss.6, 2022 (ESCI) identifier identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 54 Sayı: 3
  • Basım Tarihi: 2022
  • Doi Numarası: 10.5152/eurasianjmed.2022.20371
  • Dergi Adı: EURASIAN JOURNAL OF MEDICINE
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.6
  • Anahtar Kelimeler: Methotrexate, hepatotoxicity, silibinin, oxidative stress, thiol/disulfide, MILK THISTLE, SILYMARIN, PROTECTS, INJURY, INHIBITION, ALBUMIN
  • Kocaeli Üniversitesi Adresli: Evet

Özet

Objective: Hepatotoxicity is one of the major side effects of methotrexate and limits its use. In this study, we investigated the hepatoprotective effect of silibinin and the role of oxidative stress markers and cytokines on high-dose methotrexate-induced hepatotoxicity in rats.