Formulation of Microemulsion Systems for Improvement of Nitrofurazone Permeation Through Silicon Membrane as Burn Wound Imitating Coverage
INTERNATIONAL JOURNAL OF PHARMACOLOGY, cilt.6, sa.3, ss.264-270, 2010 (SCI-Expanded)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 6 Sayı: 3
- Basım Tarihi: 2010
- Dergi Adı: INTERNATIONAL JOURNAL OF PHARMACOLOGY
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED)
- Sayfa Sayıları: ss.264-270
- Kocaeli Üniversitesi Adresli: Hayır
Özet
The basic objective of this study was to formulation of microemulsion for improvement of nitrofurazone permeation through silicon membrane and comparison between barrier properties of third-degree burned eschar and silicon as burn wound imitating coverage. Microemulsions were prepared with titration method and for evaluation the effect of parameter on barrier properties, three independent factors: proportion of surfactant/ co surfactant, percent of oil phase and Propylene Glycol (PG) as co surfactant were selected. The effect of independent variables on permeability parameters such as flux, D and T,g were studied. Results showed, silicon performed less permeable membrane than eschar. The effects of microemulsion parameters on nitrofurazone permeability across silicon were not significant, but PG with effect on partitioning phenomena, increased flux and isopropyl myristate increased D.