Smoking and schizophrenia: Where is the biological connection?


Uneri O., Tural U., Memik N.

TURK PSIKIYATRI DERGISI, vol.17, no.1, pp.55-64, 2006 (Journal Indexed in SSCI) identifier identifier identifier

  • Publication Type: Article / Review
  • Volume: 17 Issue: 1
  • Publication Date: 2006
  • Title of Journal : TURK PSIKIYATRI DERGISI
  • Page Numbers: pp.55-64
  • Keywords: smoking, nicotine, schizophrenia, dopamine, nicotinic acetylcholine receptor, BRAIN NICOTINIC RECEPTORS, MONOAMINE-OXIDASE B, ALZHEIMERS-DISEASE, CIGARETTE-SMOKING, PARKINSONS-DISEASE, COGNITIVE PERFORMANCE, PSYCHIATRIC-DISORDERS, CARDIOVASCULAR HEALTH, NUCLEUS-ACCUMBENS, MAJOR DEPRESSION

Abstract

Objective: Patients with psychiatric disorders have a higher incidence of smoking than the general population. In particular, the rate of smoking among patients with schizophrenia has been found to be between two and three times in the general population in western countries. This paper reviews the biological factors that might be contributing to the high rate of smoking among patients with schizophrenia and examines the interaction between nicotine and neurobiological disturbances observed in schizophrenia.