Histologic outcome of thyroid nodules with repeated diagnosis of atypia in thyroid fine-needle aspiration biopsy

SELEK A., Cetinarslan B., Kivrakoglu E., Karadag D., Tarkun I., CANTÜRK Z., ...More

FUTURE ONCOLOGY, vol.12, no.6, pp.801-805, 2016 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 12 Issue: 6
  • Publication Date: 2016
  • Doi Number: 10.2217/fon.15.347
  • Journal Name: FUTURE ONCOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.801-805
  • Keywords: thyroid atypia of undetermined significance, thyroid cancer, thyroid fine-needle aspiration biopsy, thyroid follicular lesion of undetermined significance, UNDETERMINED SIGNIFICANCE, BETHESDA SYSTEM, MALIGNANCY, CYTOLOGY, LESIONS, CYTOPATHOLOGY, TERMINOLOGY, SYNOPSIS, STATE, FNA
  • Kocaeli University Affiliated: Yes

Abstract

Aim: We hypothesized that the estimated risk of malignancy for atypia of undetermined significance/follicular lesion of undetermined significance (AUS/FLUS) is higher than anticipated in Bethesda system. Therefore, we analyzed the actual malignancy risk of repeated AUS/FLUS diagnosis of thyroid fine-needle aspiration biopsies (FNAB). Materials & methods: We reported retrospective analyzes of 112 cases with repeated AUS/FLUS diagnosis among 10,769 thyroid FNABs. The histologic follow-up were evaluated in the study. Results: 112 cases with a repeated diagnosis of AUS/FLUS, histologic follow-up revealed 56 (50%) benign, 46 (41%) malignant and ten (9%) well-differentiated tumors of uncertain malignant potential outcome. Conclusion: The malignancy risk of AUS/FLUS category in thyroid FNABs was higher than anticipated in Bethesda system. Therefore, the management strategy of AUS/FLUS should be revised.