Gene polymorphisms of endothelial nitric oxide synthase enzyme associated with pulmonary hypertension in patients with COPD

Yildiz P., Oflaz H., Cine N. , Erginel-Unaltuna N., Erzengin F., Yilmaz V.

RESPIRATORY MEDICINE, cilt.97, ss.1282-1288, 2003 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 97 Konu: 12
  • Basım Tarihi: 2003
  • Doi Numarası: 10.1016/j.rmed.2003.06.001
  • Sayfa Sayıları: ss.1282-1288


In this cross-sectional controlled study, we aimed to investigate the rote of polymorphisms of the angiotensin-converting enzyme (ACE) and endothelial nitric oxide synthase (eNOS) genes on pulmonary hypertension (PH) in patients with chronic obstructive pulmonary disease (COPD). Forty-two (41 mate, 1 female, mean age: 62 +/- 7 years) COPD patients and 40 (all mate, mean age: 60 +/- 8 years) healthy controls were included. Respiratory function tests, arterial blood gases, and echocardiographic examinations were performed. ACE and eNOS genotypes were determined using PCR.